The E1 Proteins
نویسندگان
چکیده
The papillomavirus E1 protein is the ‘initiator’ protein for viral DNA replication and thus plays a critical role in maintenance of the viral genome as an episome during the viral life cycle. E1 shows some sequence and structural similarities to the simian virus 40 and polyomavirus large T antigen initiators (12), and its biochemical properties are consistent with its role as a replication initiator protein. In BPV, E1 is a nuclear phosphoprotein with origin binding, ATPase, and DNA helicase activities.
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